2007;73:1267-74). (Phila) 2014;7:958-67 ). Kaempferol is a flavonoid that acts as an antioxidant. Benefits to the skin include: Anti-inflammatory and anti-aging effects. Anti-inflammatory as well as depigmenting activity was found by Rho et al. 2010;80:2042-9; Exp. (Phila) 2014;7:958-67). (Tokyo) 2012;60:1171-5, J. Eur. in 2011 to be associated with kaempferol and kaempferol rhamnosides isolated from Hibiscus cannabinus (Molecules 2011;16:3338-44). Another study found that kaempferol, together with other flavonoids such as apigenin and luteolin, has analgesic and anti-inflammatory effects contained in the Cassia siamea Lam. In the investigation of the effects of kaempferol -3,7-O- (alpha)-dirhamnoside (kaempferitrin) on serum glucose levels for its antioxidant potential and hypoglycemic effect found that the hypoglycemic effect of kaempferitrin in diabetic rats was evident at all doses tested (50, 100, and 200 mg/kg), and this profile was maintained throughout … A study also found out that upon the investigation of neuroprotective effects of kaempferol in the mouse model of Parkinson’s disease, kaempferol prevented the loss of TH-positive neurons induced by MPTP, a prodrug to the neurotoxin MPP+, which causes permanent symptoms of Parkinson’s disease. Dermatol. See our Other Publications. It is a yellow crystalline solid having melting point of 276–278 °C (529–532 °F). MDedge: Keeping You Informed. Work by Kim et al. reported in 2010 that the inhibition by kaempferol of phosphatidylinositol 3-kinase (PI3K) activity, a key factor in carcinogenesis, and its concomitant effects may account for the chemopreventive activity of the flavonol (Carcinogenesis 2010;31:1338-43). Pharmacol. Acad. 2010;80:2042-9; Chem. found that extracts of Aceriphyllum rossii (native to Korea and China) and its active constituents, quercetin and kaempferol, blocked secretion of beta-hexosaminidase and histamine; lowered the production and mRNA expression of interleukin-4 and TNF-alpha; and reduced prostaglandin E2 and leukotriene B4 synthesis as well as the expression of cyclooxygenase-2 (COX-2) and 5-lipoxygenase. Unauthorized use prohibited. Study shows that kaempferol acts as chemopreventive agent that inhibits cancer cells formation. Res. demonstrated that kaempferol alleviated burn injuries in mice and that expression of tumor necrosis factor–alpha (TNF-alpha) induced by burn injuries was reduced by kaempferol. J. Dermatol. It also lessens the risk of cardiovascular diseases. 2001;67:515-9). Sci. 2014;62:3750-8). Ginkgo leaf extract contains quercetin and kaempferol, natural plant flavonoids that act as antioxidants, and help fight free radicals. Dermatol. 2002;53:27-34). found that kaempferol acted as a safe and potent inhibitor of solar ultraviolet-induced mouse skin carcinogenesis that acted by targeting RSK2 and MSK1 (Cancer Prev. Significantly, kaempferol is known to exhibit anticancer, anti-inflammatory, antioxidant, cytoprotective, and antiapoptotic activity (Cancer Prev. More research is necessary to determine the effectiveness of topical products intended to harness the benefits of this flavonoid as proper formulation is challenging. This site is part of the Natural News Network © 2012 All Rights Reserved. It is titled for 17th-century German naturalist Engelbert Kaempfer. This indicated that the plant’s leaf extracts have a potential for cancer chemopreventation and can be claimed as a therapeutic agent against cancer. 2006;54:2951-6; Cancer Prev. Food Chem. Intake of kaemferol helps to lower chances of cancers and possible for treating cancer. Chem. (Tokyo) 2012;60:1171-5; J. Eur. Another study found that Kaempferol-3-O-sophoroside (KPOS) possessed barrier integrity activity, inhibitory activity on cell adhesion, and migration to endothelial cells by blocking the activation of NF-κB expression and production of TNF-α which then endorsed its usefulness as therapy for vascular inflammatory diseases. Privacy | Terms All content posted on this site is commentary or opinion and is protected under Free Speech. http://www.phytochemicals.info/phytochemicals/kaempferol.php, Linolelaidic acid is an omega-6 trans fatty acid and a geometric isomer of linoleic acid.…, Fiber isn’t a single nutrient but a family of plant-based nutrients that are generally resistant…, Niacin is more commonly recognized as vitamin B3 and is part of the B-complex vitamins.…, Flavonoids constitute a large class of phytochemicals that are widely distributed in the plant kingdom,…, Lutein and Zeaxanthin facts and food sources, Vitamin K2 food sources and health benefits, Facts and Food Sources of Linolelaidic acid. In 2014, Yao et al. 2013 June 27 [doi:10.1111/jdv.12204]). 2002;53:27-34). At the end of that year, Lee et al. Do you have information you’d like to share on kaempferol? In addition, kaempferol is a key component in Punica granatum, which has been found to act as an effective protector against UVB-induced photodamage and aging in cultured skin fibroblasts (Int. Kaempferol, a yellow-colored powder, is a flavonoid that can be found in various natural resources such as apples, onions, leeks, citrus fruits, grapes, red wines, and ginkgo biloba. Like quercetin, kaempferol is an exciting polyphenolic compound that you should be watching for new health-related research. Kaempferol is a natural flavonol which is a natural flavonol or flavonoid found in various plants and plant derived foods. These and other findings led the investigators to conclude that A. rossii and its active ingredients kaempferol and quercetin may be effective agents for the treatment of immediate-type hypersensitivity (J. Agric. Truth Publishing assumes no responsibility for the use or misuse of this material. 2012;60:6966-76). Among 35 flavonoids tested by Cos et al. Flavonoids quercetin and kaempferol are effective than additive effects of each flavonoid. flavonoid that can be found in various natural resources, 8 Amazing Health Benefits Of Eating Quinoa, Broccoli, The medicinal properties of a superfood, Berries and Onions Slash Pancreatic Cancer Risk By Up To 59 Percent, Spinach Knocks Out Cancer and Boosts Brain Power, Glucophage – uses, health risks, and side effects at NaturalPedia.com, Norvasc – uses, health risks, and side effects at NaturalPedia.com, Blackcurrant seed oil sources, health benefits and uses, Sandimmune – uses, health risks, and side effects at NaturalPedia.com. The investigators concluded that kaempferol is among the flavonoids or plant extracts containing them that may be useful as an agent to protect against photoaging and to treat some cutaneous inflammatory conditions (Planta Med. 2010;80:2042-9). Res. The information provided is for educational purposes only. Food Chem. It helps to prevent arteriosclerosis hindering oxidation of low density lipoprotein and platelet formation in blood. found that kaempferol inhibited UVB-induced COX-2 protein expression in mouse skin epidermal JB6 P+ cells, by blocking Src kinase activity and attenuated the UVB-induced transcriptional activities of COX-2 gene and the transcription factor AP-1. recently showed that submicron emulsions are effective carriers for the transdermal delivery of kaempferol (Chem. (Phila) 2014;7:958-67; Biochem. It is not intended as a substitute for professional advice of any kind. Res. Kim and colleagues have also shown in animal studies that the topical application of P. persica may be effective at thwarting UVB-induced skin damage (J. Cosmet. 2010;49:276-82). Pharm. found that kaempferol acted as a safe and potent inhibitor of solar ultraviolet-induced mouse skin carcinogenesis that acted by targeting RSK2 and MSK1 ( Cancer Prev. Health Benefits of Kaempferol Kaempferol is a strong antioxidant which helps to prevent oxidative damage of cells, DNA and lipids. Bull. Pharm. Aside from its cancer-fighting properties, kaempferol acts as an antioxidant and protects the body from damaging free radicals, which are harmful by-products of oxygen-based reactions. (Phila) 2014;7:958-67; Biochem. It also acts as an antidepressant and enhances metabolism. Research on kaempferol is scarce in humans in supplemental form, but in vitro research seems promising. Health Benefits. It possesses antioxidant properties that help to lower oxidative stress. Kaempferol was found to be good for people who suffer from osteoporosis. 2010;80:2042-9 ). in 2002 revealed that four kaempferol glycosides are key active ingredients in the flowers of Prunus persica, which has long been used in traditional Chinese medicine to treat skin disorders (J. Cosmet. Kaempferol is one of the many flavonoids found in foods alongside others like luteolin and quercetin. Sci. These components may result in anti-inflammatory and anti-aging effects. Kaempferol might improve bleomycin-induced fibrosis by reducing oxidative stress, inflammation, and oxidative cellular damage. Thursday, September 21, 2017 by Michelle Simmons, http://www.naturalpedia.com/kaempferol-sources-health-benefits-and-uses.html. Kaempferol was found to be good for people who suffer from osteoporosis. Acad. All trademarks, registered trademarks and servicemarks mentioned on this site are the property of their respective owners. Study shows that kaempferol acts as chemopreventive agent that inhibits cancer cells formation. All four flavonoids also suppressed the activation of activator protein (AP)-1. In a study, it was found out that flavonols quercetin and kaempferol significantly increased alkaline phosphate (ALP) activity which then can stimulate osteoblastic activity. See more with MDedge! Food Chem. Kaempferol also hindered p38 mitogen-activated protein kinase c-Jun N-terminal kinase (JNK) activation. (Tokyo) 2012;60:1171-5). stem bark extracts. All rights reserved. 2013 June 27 [doi:10.1111/jdv.12204, Manage Your Dermatology Practice: Managing Difficult Patient Encounters, Expert Insights in Hidradenitis Suppurativa, Treating Patients with Acne by Telemedicine in the Era of COVID-19, Nurse Practitioners / Physician Assistants. Venereol. Acad. Hypoglycemic and antioxidant effects. Kaempferol is becoming an exciting nutritional compound with promise for reducing the risks of developing certain types of cancer and inflammatory-based diseases.  It can help prevent cancer, diabetes, and heart disease. They concluded that kaempferol exerts robust chemopreventive activity against skin cancer by suppressing Src (Biochem. They concluded that their findings suggest the possible application of kaempferol to treat thermal burn–induced skin injuries (BMB Rep. 2010;43:46-51). It is showing promise in and of itself in being an anti-obesity agent and anti-cancer agent. Pharmacol. Pharmacol. Bull. In the research of kaempferol, it was discovered that rats treated with the flavonol exhibited significantly higher bone mineral density in the trabecular regions â femur neck, proximal tibia, and vertebrae â and lowered serum ALP. It is highly soluble in ethers, hot ethanol, DMSO and slightly soluble in water. Your use of this website indicates your agreement to these terms and those published here.
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